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Mainly through these mechanisms (27), Pycnogenol ® supplementation has been shown in RDP human clinical trials to beneficially affect cardiovascular health (9, 11, 12, 20–22, 28–31), chronic venous insufficiency (32, 33), cognition (13, 14, 34–39), joint health (40–42), skin health (43, 44), eye health (45, 46), women’s health (12, 47, 48), respiratory health and allergies (49–51), oral health (52) and sports performance (53–56) (Figure 2)
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